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There is a risk of myelosuppressionMonitoring blood counts weekly throughout the duration of therapy should be emphasized to patients taking HYDREAsee WARNINGS AND PRECAUTIONSAdvise patients to report signs and symptoms of infection or bleeding immediatelyAdvise patients that there is a risk of cutaneous vasculitic toxicities and secondary malignancies including leukemia and skin cancerssee WARNINGS AND PRECAUTIONSAdvise females of reproductive potential of the potential risk to a fetus and to inform their healthcare provider of a known or suspected pregnancyAdvise females and males of reproductive potential to use contraception during and after treatment with HYDREAsee WARNINGS AND PRECAUTIONS and Use in Specific PopulationsAdvise patients to inform their healthcare provider if they have received or are planning to receive vaccinations while taking HYDREA as this may result in a severe infectionsee WARNINGS AND PRECAUTIONSAdvise females to discontinue breastfeeding during treatment with HYDREAsee Use in Specific PopulationsPatients with HIV infection should contact their physician for signs and symptoms of pancreatitishepatic eventsand peripheral neuropathysee WARNINGS AND PRECAUTIONSPostirradiation erythema can occur in patients who have received previous irradiation therapysee WARNINGS AND PRECAUTIONS

Your red blood cells are responsible for carrying oxygen to the tissues in your bodyWhen the red cell count is lowyou may feel tired or weakYou should let your oncology care team know if you experience any shortness of breathdifficulty breathing or pain in your chestIf the count gets too lowyou may receive a blood transfusion.

It is important to make sure you are taking the correct amount of medication every timeBefore every dosecheck that what you are taking matches what you have been prescribed.

You may be given folic acid supplements to prevent a side effect called macrocytosis which is an enlarging of red blood cellsCertain medications can interfere with this medicationso make sure your provider is aware of all the medicationsvitamins and supplements you are taking.

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advise females of reproductive potential to use effective contraception during and after treatment with hydrea capsules for at least 6 months after therapy.

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